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USRuleOfficial ✓August 12, 2026· Federal Register

Schedules of Controlled Substances: Temporary Placement of O-Desmethyltramadol in Schedule I

What happened

The Drug Enforcement Administration (DEA) issued a temporary order to classify O-desmethyltramadol (O-DSMT), including its isomers, esters, ethers, salts, and salts of isomers, esters and ethers, as a Schedule I controlled substance. This action was signed by Donald Trump and is effective from August 12, 2026, until August 12, 2028. The DEA based this decision on a finding that it is necessary to avoid an imminent hazard to public safety.

Why it matters

This order imposes strict regulatory controls, administrative, civil, and criminal penalties on O-DSMT. Substances in Schedule I have a high potential for abuse and no accepted medical use, meaning its handling will be severely restricted. It means anyone involved with O-DSMT will face legal consequences for unauthorized activities.

Who it affects

  • Manufacturers of O-DSMT
  • Distributors of O-DSMT
  • Importers of O-DSMT
  • Exporters of O-DSMT
  • Researchers of O-DSMT
  • People possessing O-DSMT
Receipts

The receipts are official. The summary is ours.

Read on Federal Register

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